Si bien las sustancias elaboradas mediante los procesos alquímicos gozaban de la máxima actividad farmacológica, sólo unos afortunados eran capaces de prepararlas. Ésa es una de las razones que condujeron al franciscano Juan de Rupescissa a proponer, a mediados del siglo XIV, su teoría de la quintaesencia para elaborar remedios de alto poder
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